Our study proved that most of right-sided colonic adenocarcinomas potentially going through the serrated pathway, are CK7+/p53−/MLH-1−/BRAF-mutated/K-ras-wt/MSI, but those located in the distal colorectal segments are more frequently CK7+/CK20+/p53−/MLH-1+/BRAF wt/K-ras-mutated/MSS cases. Here, MLH1 is linked to colon adenocarcinoma.