VEGFA and wet macular degeneration: Several VEGF antagonists have been developed for treatment of wet AMD including Pegaptanib (Macugen; Eyetech Pharmaceuticals, Inc., New York, NY, USA), Ranibizumab (Lucentis; Genentech, Inc., San Francisco, CA, USA), and VEGF Trap-Eye (Regeneron Pharmaceuticals, Inc., New York, NY, USA).