Our data pointed out that BRCA1 mutation screening is mandatory for young Brazilian patients diagnosed with HR(−) and/or TN breast tumors, specially when it occurs in combination with FH(+), supporting previous studies that have reported an increased probability of BRCA1 germline mutation in_young patients with FH(+) and TN tumors [35]–[37]. This evidence concerns the gene BRCA1 and breast neoplasm.