BRCA1 and invasive ductal breast carcinoma: Tumors from two affected sisters (IDs 2007 and 2012) whose germline UV identified in the index patient (ID 2007) was confirmed in the sister (ID 2012) (BRCA1- p.S1655P) were discriminated into two different cluster ramifications; these two tumors were of different subtypes: one was TN, high-grade and atypical medullar, while the other was invasive ductal carcinoma, ER(+), HER(−) and of histological grade 2.