The goal of this experiment was three-fold: 1) to evaluate efficacy of resveratrol and PTER in inhibiting orthotopic PCa growth and progression; 2) to assess the role of MTA1 in prostate tumor development, progression and metastasis, and 3) to determine whether MTA1 affects the susceptibility of primary prostate tumor and metastasis to resveratrol and PTER. This evidence concerns the gene MTA1 and posterior cortical atrophy.