AQP5 and pulmonary fibrosis: The relevance of our findings in human pathological conditions such as lung fibrosis may be of clinical interest: Recently, Gabazza et al. [36] showed that AQP-5 expression is decreased in the fibrotic lung of mice treated with bleomycin, and since lung fibrosis often leads to systemic hypoxia, it is possible that it is hypoxia, rather than the fibrosis itself, that results in reduction of AQP5 expression.