Both HI (hazard ratio (HR)  =  0.64, 95% CI: 0.44 to 0.94 for dying from breast cancer with increasing HI) and the tumor p53 mutation status (HR  =  1.66, 95% CI: 1.02 to 2.7 for a p53 mutation carrier vs. non-carrier) were significantly associated with survival in the univariable analysis, but not education (HR  =  0.76, 95% CI: 0.45 to 1.26). The gene discussed is TP53; the disease is breast cancer.