ABCG2 and Miyoshi myopathy: Fig. S1A depicts SP cells from the RPMI 8226, KMS-12-BM, AMO1 and KMS-11 lines: low-level accumulation of intracellular Hoechst 33342 is characteristic of SP cells (left panel), and the population disappears when the cells are treated with an ABC transporter inhibitor such as verapamil (100 μM; middle panel) or reserpine (50 μM; right panel). In fact, verapamil and reserpine reduced detection of SP cells in all cell lines examined with no significant cytotoxicity (Fig. S2). Fig. S1B shows the SP and MP fractions (%) in 14 MM cell lines, with and without verapamil or reserpine treatment.