Some studies showed that IL28B genotypes were not associated with recovery from HBV infection, clearance of HBeAg and HBsAg, hepatitis activity and liver cirrhosis [35], [36], while other studies showed significant correlations between IL28B genotypes and HBV viral load, hepatic inflammation and risk of HCC [37], [38]. The gene discussed is IFNL3; the disease is hepatocellular carcinoma.