Genome-wide association studies have shown that single-nucleotide polymorphisms (SNPs) at or near the interleukin 28B gene (IL28B) region on chromosome 19, which encodes interferon-lamda 3 (IFN-λ3), are associated with spontaneous hepatitis C virus (HCV) clearance and sustained virological response (SVR) in patients with chronic hepatitis C (CHC) treated with pegylated-interferon (PEG-IFN) and ribavirin [9], [10], [11], [12], [13]. This evidence concerns the gene IFNL3 and cryohydrocytosis.