GHSR and obesity due to melanocortin 4 receptor deficiency: However, contrary to that previously reported at the hypothalamic and pituitary level [17], [19], we observed an up-regulation of ghrelin, In1-ghrelin and GHS-R transcripts at the pancreas of cort+/+ (control) animals under obesity conditions, while GOAT expression level remains unaltered, thus supporting that obesity-induced alterations in the ghrelin-system are tissue-dependent.