SFRP-1 and the SFRP-like molecule V3Nter can inhibit Wnt signaling and expression of the β-catenin target genes - cyclin D1 and c-myc, finally inhibiting tumor growth of β-catenin-activated tumor cells such as colon cancer SW480 and HCT-116 cells [66]. The gene discussed is CCND1; the disease is colonic neoplasm.