According to George, Sawada, and Kato [9], [60], [61], who separately studied spatiotemporal expression patterns of TNF-α during WD, TNF-α expression is enhanced promptly after nerve injury in the distal stump, peaking between day 1 and day 3 post-injury, and returning to baseline levels as early as day 7. The gene discussed is TNF; the disease is Wilson disease.