COX-2, in particular, is an inducible Cox isozyme, and COX-2 overexpression is closely associated with human tumour formation by the production of large amounts of various prostaglandins (PGs), such as prostaglandin E2, thromboxane B2 and prostacyclin, which in turn cause the promotion of cellular proliferation, cancer invasiveness, angiogenesis and anti-apoptosis [11], [12]. The gene discussed is PTGS2; the disease is cancer.