FBXO31-SCF joins a small number of E3 ligases, which are positioned at the centrosome including dendrite-regulating Cdc20-APC and the Parkinson’s disease protein Parkin [40]–[42], supporting an essential role for centrosomal E3 ubiquitin ligases in neuronal development and disease [43], [44]. This evidence concerns the gene FBXO31 and glycogen storage disease VI.