The Akt inhibitor perifosine is currently evaluated in phase III clinical trials against various cancers whereas the allosteric Akt inhibitor MK-2206 has reached phase I. To overcome the problem of feedback regulation within the PI3K/Akt pathway dual PI3K/mTOR inhibitors seem to be promising and several companies pursue such compounds in phase I or phase II clinical trialsCourtney et al. [5]. The gene discussed is AKT1; the disease is cancer.