SYP and amyotrophic lateral sclerosis: In the present study, we used markers of the different elements of the NMJ: neurofilament (NF) and synaptophysin to study the nerve endings, S100B, p75 neurotrophin receptor (p75NTR) and glial fibrillary acidic protein (GFAP) to study the terminal Schwann cells, and α-bungarotoxin to detect the muscle side of the synapse, in order to further elucidate the differences in the impact of ALS on EOM vs limb NMJs.