In this study, we confirm that although E-cadherin expression is reduced with Reishi treatment in vivo, epithelial to mesenchymal transition does not occur as shown by lower Vimentin levels in the tumors, and neither do we see a subsequent increase in proliferation due to a potential β-catenin translocation into the nucleus, as demonstrated by lower proliferation rates shown by reduced Ki-67 tumor levels. This evidence concerns the gene CDH1 and neoplasm.