G. lucidum extract (GLE), containing polysaccharides and triterpenes, was reported to suppress growth and metastatic potential of human MDA-MD-231 breast cancer cells by inhibiting the activity of Akt and transcription factors AP-1 and NF-κB, resulting in the downregulation of expression of cyclin D1 [6], [7], [8]. The gene discussed is JUN; the disease is breast carcinoma.