Pro-platelet basic protein (PPBP, also called connective tissue-activating peptide III [CTAP III] or neutrophil activating protein-2 [NAP-2]), a CXC chemokine member involved in angiogenesis, tumorigenesis and metastasis [18], and haptoglobin, an acute-phase plasma glycoprotein that binds to hemoglobin and prevents oxidative stress [19] have both been identified as potential biomarkers to detect preclinical lung cancer [20]. This evidence concerns the gene HP and lung cancer.