On the contrary, the MDS malignant clones in the older patient might not be controlled by the weaker T-cell response (demonstrated by the presence of fewer CFUs compared with the younger patients after the deletion of the activated CD4 or CD8 cells) and the activated TSGs, although some of the tumor-targeted T cells (such as Tc1 and NK) number expanded. The gene discussed is CD8A; the disease is myelodysplastic syndrome.