NOTCH3 and hepatocellular carcinoma: The Kaplan-Meier analysis of the survival curves showed a significantly worse overall survival rate for patients whose tumors had high Notch1 (log-rank test, P<0.001) and Notch3 (log-rank test, P<0.001) levels, indicating that high Notch1 and Notch3 protein levels are markers of poor prognosis for patients with HCC.