However, Li et al. showed that Notch1 down-regulation inhibits tumor growth in the human HCC cell lines HEP3B, SK-Hep-1 and SNU449 [56], whereas Qi et al. showed that Notch1 over-expression was able to inhibit the growth of SMMC7721 cells [57]. The gene discussed is NOTCH1; the disease is neoplasm.