Thus, we describe novel mechanisms following MC4R activation that may be involved in the anti-inflammatory effects of melanocortins in glial cells.Inflammation has been implicated in the pathogenesis of several neurological disorders such as Alzheimeŕs disease, Parkinsońs disease, Huntingtońs disease and Experimental Autoimmune Encephalomyelitis (EAE) [40]. Here, MC4R is linked to nervous system disorder.