PLAU and neoplasm: At the same time, prevention of TTP inactivation would be anticipated to be deleterious for cancer cells, where TTP is known to negatively regulate the expression of urokinase plasminogen activator (uPA), uPA receptor, matrix metalloproteinase-1 (MMP-1) and VEGF, thus decreasing tumor cell growth, invasion and metastasis [52], [53].