Considering that ERB analogs are effective modulators of α-synuclein implicated in Parkinson’s disease [68] and ERB itself is effective at destabilizing pre-formed Aβ fibrils,[69], halogenation of small molecules might be a general way to obtain effective modulators of other amyloidogenic peptides and proteins at multiple stages of aggregation. This evidence concerns the gene ESR2 and Parkinson disease.