FGFR1 and neoplasm: Inhibition of FGFR signaling with either BGJ-398 or FGFR1 knockdown resulted in strong suppression of invasion in vitro, and BGJ-398 blocked CTC production and metastasis (without inhibiting primary tumor growth) in mice inoculated with orthotopic, FGFR1-positive UM-UC3 tumors in vivo (Fig. 5).