RARRES2 and obesity due to melanocortin 4 receptor deficiency: Even though a relationship of elevated serum levels in obesity and metabolic syndrome has been suggested, further studies are required that will provide valuable insight to verifying the function of chemerin and determine whether excess chemerin increases adiposity and deranges metabolic function or whether elevated chemerin levels are a consequence or compensatory response during and following the development of obesity and its co morbidities which may lead to the potential therapeutic role of chemerin to these prevalent disorders.