PSEN1 and amyloidosis: In our in vivo μMRI we used absolute T2* measurements to show that in APP/PS1 Tg mice injected with USPIO-PEG-Aβ1-42, areas of the brain with amyloid deposits (cortex and hippocampus) were significant lower (corresponding to more dark spots) compared to wild-type mice injected with USPIO-PEG-Aβ1-42, as well as, APP/PS1 Tg mice injected with either UPSIO-Aβ1-42 or USPIO alone (see Table 2).