These results not only confirm the TGFBR2-dependent decreased binding of the plant lectin SNA to sialylated cell surface glycoproteins initially observed in our previous work [30], but also argue in favor of sialylation of proteins being a dynamically regulated process modulated by a major signaling pathway in colon cancer cells. This evidence concerns the gene TGFBR2 and malignant colon neoplasm.