Since about 40–50% of colorectal tumors have mutant Ras genes and about 90% of colorectal tumors have up-regulated ST6Gal1 activity and 70% of colorectal cancers are positive for the α2,6 sialic acid modification added by ST6Gal1 [50], Ras-independent but TGFBR2-mediated mechanisms of glycan alterations appear most likely. The gene discussed is TGFBR2; the disease is colorectal cancer.