Our study provides new original data and bring to light the fact that nutritional conditions in immediate postnatal life, such as overnutrition, may influence the expression of several genes involved in the heart’s structural organization (collagen, myosin, actin, dystrophin, dynein ...) metabolism and somatotropic system (insulin-growth factors), vasoreactivity (endothelin-1 and receptor), ion channels (Scn4b), cell signaling/communication (APJ) and oxidative stress (glutathione S-transferase). The gene discussed is EDN1; the disease is overnutrition.