TOP2A and breast cancer: Although, in public breast cancer datasets (grade 2, follow-up: 10 years, n = 497, split at median) all the genes showed strong predictive potential (AURKA: p = 0.047, HR = 1.33[1.00–1.78]; FOXM1: p<0.001, HR = 1.69[1.26–2.27]; TOP2A: p<0.001, HR = 1.68[1.26–2.25]; TPX2: p<0.001, HR = 1.64[1.23–2.18] for relapse-free survival (Figure S4), the data generated by qPCR was unable to distinguish prognostic subgroups for AURKA, FOXM1, and TPX2 at 10, 25, 75, 90 percentiles, median or average expression in our limited number of patients (Table S4).