Using regression analysis, considering all 185 patients, the CIN4 expression signature was significantly correlated with mitotic index (p = 0.001, Figure 3A) and Ki67 expression (p = 0.005, Figure 3C), suggesting that proliferation is correlated with tumor aneuploidy (p = 0.014, p = 0.023, respectively; Figure 3B and D). Here, MKI67 is linked to neoplasm.