[11] In this model, L-Dopa treatment ameliorated the motor deficits. [11] Interestingly, since dopamine D2-like partial agonists effectively treat respiratory disorders in the same mouse model, [12], functional alteration of genes involved in dopaminergic synapse, ATF6B and PPP2R5E, may exacerbate respiratory disorders typically observed in the 2 classical subjects. [13] Hyperventilation or breath holding was not noted in the two Z-RTT girls at any examination. Here, PPP2R5E is linked to respiratory system disorder.