Although alterations of tight junctions have been described in several models of hypoxia and stroke before [26], [28], [30], [58], [59], we were not able to correlate areas of FITC-albumin leakage with alterations in the expression pattern of the transmembrane proteins occludin and claudin-5 in this model of focal cerebral ischemia (Fig. 2). Here, CLDN5 is linked to stroke disorder.