We have previously reported that the PI3K/AKT pathway, in part, mediates GRP-induced G1-S phase cell cycle progression and that bombesin, an amphibian equivalent of GRP, induces vascularization of neuroblastoma xenografts by upregulation of vascular endothelial growth factor (VEGF) [3], [4]. The gene discussed is AKT1; the disease is neuroblastoma.