The GFP fluorescence diminished after AFP-Cre and LoxP-shRNA co-infected AFP-producing HCC cells (HCCLM3, HepG2, and Hep3B) while it did not change as AFP-Cre and LoxP-shRNA infected the non-HCC cells (L-02, Hela, and SW1116) (Fig. 3C). Here, AFP is linked to hepatocellular carcinoma.