Our previous study identified a single nucleotide polymorphism (SNP), rs3853839, in the 3′ UTR of an X-linked gene TLR7 to be associated with SLE in 4,334 cases and 4,940 controls of Eastern Asian descent [5], providing the first convincing evidence for the genetic contribution of TLR7 to human SLE. Here, TLR7 is linked to systemic lupus erythematosus.