TLR8 and systemic lupus erythematosus: Only six other SNPs within a relatively small interval of 5 kb spanning from TLR7 3′downstream to TLR8 intron 1 were consistently associated with SLE (P<0.05) in EA, AA and HS (Table S1), and remained significant trans-ancestral meta-analysis P values after Bonferroni correction (5.5×10−6≤Pmeta≤1.3×10−6, Table S1).