In summary, we have advanced our previous study by showing rs3853839 (at TLR7 3′UTR) as the most likely polymorphism responsible for the association of TLR7-TLR8 region with SLE in individuals of EA, AA and HS ancestry, and have characterized a differential miR-3148 modulation which explains the effect of allelic variation of rs3853839 on TLR7 expression. This evidence concerns the gene TLR8 and systemic lupus erythematosus.