Upon verification of comparable efficiency in the infection with STEMCCA of control and mutant MEF (Figure S1A), we analyzed the efficiency of reprogramming following Ezh2 inactivation by comparing the number of primary iPSC colonies assessed through staining with alkalyne phosphatase (AP) 7 days after doxycycline removal (Figure 1B). This evidence concerns the gene DHCR7-DT and infection.