NUMB and neoplasm: During NB divisions, cell fate determinants including Numb, Prospero (Pros), and Brain tumor (Brat) are asymmetrically localised onto one side of the NB cortex (referred to as the basal cortex) via two coiled-coil adaptor proteins, Partner of Numb (Pon, the adaptor for Numb) and Miranda (Mira, the adaptor for Pros and Brat), and are subsequently segregated into the small GMC daughter at the end of NB divisions [8]–[18].