It is possible that the association we observed between the serum iron–raising allele of rs1800562 (C282Y) in HFE and poorer word recall is an indicator of any effect of a predisposition to hemochromatosis, a syndrome often accompanied by fatigue and malaise (23), and not directly of serum iron, because this association was not observed for the rs4820268 (TMPRSS6) genotype. This evidence concerns the gene TMPRSS6 and hemochromatosis type 1.