IFNA1 and infection: Although the complex interplay between SeV and the innate immune system has not yet been described in detail, it has been found to depend on the ability of the sensor RIG-I to detect infection and on viral V and C protein levels, which interfere with IFN induction and production of IFN-stimulated gene products (Burke et al., 1998; Garcin et al., 1999, 2001; Strahle et al., 2006).