TREH and type 2 diabetes mellitus: Although bivariate analysis showed a LOD of 7.0, the estimated genetic correlation between the trehalase and T2D loci (r = −0.47) is not statistically significantly different from 0 (p = 0.09), as expected if linkage were coincidental, nor is it significantly different from −1 (p = 0.23), as expected with high pleiotropy.