ABCC6 and Pseudoxanthoma elasticum: To further enlarge the spectrum of ectopic calcification disorders which are clinically and/or pathogenetically related to PXE, there is a recent report describing a patient, bearing two ABCC6 mutations and a gain of function single-nucleotide polymorphism (SNP) in the GGCX gene, who was characterized by both classic PXE (papules, retinopathy, and calcifications) and by a PXE-like syndrome (cutis laxa beyond the flexural areas; Vanakker et al., 2011).