In these types of inflammation, granulomas are traditionally thought to confine offending agents that are difficult to eradicate.1 The cellular components of immune granulomas include macrophages, T cells (including T helper type 1 cells [Th1], T helper 17 cells [Th17], regulatory T cells [Treg], and CD8+ T cells), B cells and dendritic cells (DCs).2–5 In these immune granulomas, T cell-mediated immune responses have been shown to occur. This evidence concerns the gene CD8A and Granuloma.