Mouse transgenic models of AMD that form basal deposits include those caused by deletion/mutation of inflammatory genes (eg CFH, Ccr2, Ccl2), of genes related to oxidative stress (SOD2), metabolic pathway genes (ApoE, ApoB100) and intracellular proteases (cathepsin D, nephrilysin) [28]. The gene discussed is APOE; the disease is age-related macular degeneration.