DNMT inhibitory activity is associated with demethylation and reactivation of several methylation-silenced genes such as p16, RARβ, MGMT, MLH1, BTG3 and GSTP1 in human cancer cells, suggesting a possible chemopreventive effect due to epigenetic modification induced by these dietary botanicals [25], [26]. The gene discussed is DNMT1; the disease is cancer.