In this context, over the past years through an integrated chemical biological strategy, we obtained four natural-like synthetic biphenyl and terphenyl compounds, IND_S1, MEL_T1, IND_S7 and MEL_S3 (Figure 1), able to interfere with the signaling cascades conferring apoptosis resistance and uncontrolled proliferation to BCR-ABL-expressing leukemia cells [12], [13]. The gene discussed is ABL1; the disease is leukemia.