TARDBP and amyotrophic lateral sclerosis: Amyotrohpic lateral scleorsis (ALS) is a progressive neurodegenerative disorder that affects motor and extra-motor systems, and shares the pathologic hallmark of neuronal inclusions immunoreactive to TAR-DNA binding protein of ∼43 kD (TDP-43) with many cases of frontotemporal degeneration (FTD).