While there was no difference in fasting ASP levels (Obese: 16.1±1.1 and T2D: 13.4±1.3 pmol/l, p = NS), plasma ASP levels correlated positively with BMI (r = 0.565, p = 0.044), insulin (r = 0.584, p = 0.036), triglycerides (r = 0.586, p = 0.035) and IMCL in type 2 muscle fibers (r = 0.680, p = 0.011), and negatively with C5L2 expression (r = −0.585, p = 0.046) in the obese group only. Here, C3 is linked to type 2 diabetes mellitus.