The present study was undertaken to elucidate the role of dietary selenium and selenoproteins in hepatocarcinogenesis in mice carrying TGFα, which is a liver cancer driver transgene [16], and/or a mutant TrsptG37 transgene, that disrupts stress-related selenoprotein biosynthesis [13]–[15] and enhances carcinogenesis in other organs [10], [11]. The gene discussed is SELENOS; the disease is liver cancer.