The human microarray analysis (Fig. 3B) suggests that during HIV-1 infection in humans, higher SerpinB2 mRNA levels correlate with suppression of Th1 (T-bet) responses; a Th1 modulation similar to that seen in SerpinB2−/− mice after vaccination with a Th1-promoting vaccine [4]. Here, SERPINB2 is linked to HIV-1 infection.