ITIH4 and HIV infectious disease: In vitro experiments have reported induction of SerpinB2 (i) in macrophages by gp120 from M-tropic HIV [7], (ii) in monocyte-derived dendritic cells by HIV infection [8] and (iii) in peripheral blood mononuclear cells (PBMCs) stimulated with baculovirus-expressed HIV Pr55gag virus-like particles [9].