The induction of SerpinB2 mRNA in PBMCs after infection of monkeys with the M-tropic SIVmac251 is consistent with microarray studies showing significantly increased SerpinB2 mRNA in circulating monocytes from HIV-1 infected patients and supports the general concept that monocyte/macrophage SerpinB2 is often induced during infection and inflammation [1]. The gene discussed is SERPINB2; the disease is infection.