The SerpinB2 mRNA levels in EcoHIV infected mice decreased significantly by ≈50% on days 21 and 41 post infection in both PECs (p = 0.032 and 0.008, respectively) and spleen (p = 0.029 and 0.016, respectively) (Fig. 2A). The gene discussed is SERPINB2; the disease is infection.