FAS and neoplasm: Most previous reports on TRAIL-receptors expression in different tumor entities were based on semi-quantitative criteria [22], [26], [29]; however, recent studies have shown that particularly the sub-cellular localisation of TRAIL-receptors might influence their function; specifically, while internalization of the pro-apoptotic receptor CD95 plays a stimulatory role in the transduction of apoptotic signalling, internalization of TRAIL-receptors inhibits caspase activation [30].