However, membrane staining for TRAIL-R2 was associated with a better prognosis in a subgroup of patients without nodal metastases at the time of surgery, which is consistent with recent evidence that the fraction of membrane-bound receptors determines their functional status [11], [31] and plays a major prognostic role in patients with hepatocellular carcinoma [8]. The gene discussed is TNFRSF10B; the disease is hepatocellular carcinoma.