STAT3 and myocardial infarction: Conversely, Hilfiker-Kleiner et al have reported that mice displaying heart-specific enhanced STAT3 activity due to the expression of a mutated intracytoplasmic sequence of mouse gp130 (gp130Y757/fl) showed excessive inflammatory responses and lethality upon myocardial infarction (Hilfiker-Kleiner et al, 2010).