TRPV4 and Stroke: Among them, TRP vanilloid 4 (TRPV4) is attracting more and more attention because it can be activated by multiple stimuli including hypotonic stimulation, cell swelling, mild heat (>24-37°C), arachidonic acid (AA), and its metabolism epoxyeicosatrienoic acids (EETs; Plant and Strotmann, 2007), some of which may happen during stroke.